Cerebrospinal fluid (CSF) diagnostics are pivotal for rapid evaluation of meningitis/encephalitis, subarachnoid haemorrhage, demyelinating disease (OCB/IgG index/k-FLC), autoimmune/paraneoplastic syndromes, neoplastic infiltration (cytology/flow cytometry), prion disease (RT-QuIC), and neurodegeneration (Aβ42/40, total tau, p-Tau181/217, NfL). At Southern Medical Supplies Limited (SMSL), we support an end-to-end CSF workflow: cell count & differential, protein/glucose/lactate, Gram stain/culture & susceptibility, cryptococcal antigen and other targeted antigens, syndromic multiplex NAAT/RT-PCR for common pathogens (e.g., HSV/VZV/EV, S. pneumoniae, N. meningitidis, L. monocytogenes, TB where indicated), autoimmune/AE and PNS antibody panels, OCB with IgG index/kappa free light chains, and neuro biomarker panels with matched serum–CSF interpretation. Our solutions span clinical chemistry, immunoassay/ELISA, immunofluorescence, molecular PCR/RT-PCR, microbiology, and flow cytometry platforms sourced from a broad network of trusted partners—EUROIMMUN, Ansh Labs, Randox, Streck, Bio-Rad, Abbott, Roche, Siemens Healthineers, Qiagen, bioMérieux, Cepheid, Werfen, Globe Scientific, ELGA LabWater, LW Scientific, Sebia, LTA SRL, Acrobiotech, MAKOL Innovacion Medica, Rayto Life and Analytical Sciences, Diazyme, Hardy’s Diagnostics, and Teco Diagnostics—delivering the speed, sensitivity, and reproducibility clinicians need for confident CSF-based diagnosis and monitoring.