Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neuron disease diagnosed clinically and supported by targeted laboratory testing that rules out mimics and documents neuronal injury. At Southern Medical Supplies Limited (SMSL), we offer a comprehensive work-up including neuronal injury biomarkers in serum/CSF (neurofilament light [NfL], phosphorylated neurofilament heavy [pNfH]), muscle injury markers (CK), and differential diagnosis panels such as anti-GM1 for multifocal motor neuropathy, AChR/MuSK where myasthenia is considered, autoimmune screens (ANA/ENA), metabolic and nutritional studies (B12/folate, thyroid), and infectious rule-outs (HIV, HTLV-1, syphilis, Lyme as relevant). For suspected familial or early-onset disease, we provide molecular testing including C9orf72 hexanucleotide repeat, SOD1, TARDBP, FUS, VCP, OPTN, TBK1, SQSTM1 and broader neurogenetic panels. Our portfolio spans ELISA, chemiluminescent immunoassay, molecular, and clinical chemistry platforms sourced from a wide network of trusted partners—EUROIMMUN, Ansh Labs, Randox, Streck, Bio-Rad, Abbott, Roche, Siemens Healthineers, Qiagen, bioMérieux, Cepheid, Werfen, Globe Scientific, ELGA LabWater, LW Scientific, Sebia, LTA SRL, Acrobiotech, MAKOL Innovacion Medica, Rayto Life and Analytical Sciences, Diazyme, Hardy’s Diagnostics, and Teco Diagnostics—delivering the analytical sensitivity, specificity, and reproducibility needed to complement clinical and neurophysiology evaluations in ALS care.